Light-responsive bicyclic peptides
WebOct 2, 2024 · Bicyclic peptides are high-value molecular scaffolds for the discovery of potent ligands and there exist one published example of synthesis of light-responsive … WebFrom a large combinatorial library of chemically constrained bicyclic peptides we isolated a selective and potent (Ki = 53 nM) inhibitor of human urokinase-type plasminogen activator (uPA) and crystallized the complex. This revealed an extended structure of the peptide with both peptide loops engaging the target to form a large interaction surface of 701 Å2 with …
Light-responsive bicyclic peptides
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WebNov 6, 2013 · Light-responsive ligands are useful tools in biochemistry and cell biology because the function of these ligands can be spatially and temporally controlled. Conventional design of such ligands... WebMacrocyclic peptides are an interesting molecular format for drug discovery, 1 combining the advantages of small-molecule and biological therapeutics: synthetic accessibility, low …
WebJan 11, 2024 · In a recent OBC publication, the group of Professor Ratmir Derda of the University of Alberta discusses a strategy to develop libraries of light-responsive (LR) ligands, which can be produced by grafting known LR structures, such as azobenzene, onto molecules with established biological activity. WebAug 23, 2012 · Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long-standing focus within peptide research is the creation of structurally constrained peptides generated through cyclization.
WebIn this paper, we describe a method for the synthesis of light-responsive (LR) bicyclic macrocycles from linear peptides composed of 20 natural amino acids. Research articleAbstract only Studies toward the synthesis of strevertenes A and G: stereoselective construction of C1–C19 segments of the molecules WebIn this paper, we describe a method for the synthesis of light-responsive (LR) bicyclic macrocycles from linear peptides composed of 20 natural amino acids. Small molecules, …
WebFrom independent research at Tufts University: T. Hui, † M. L. Descoteaux, † J. Miao, † Y.-S. Lin , “Training neural network models using molecular dynamics simulation results to efficiently predict cyclic hexapeptide structural ensembles,” submitted. † Equal …
WebAug 23, 2012 · Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long … 14本流派WebApr 7, 2024 · 1 Introduction. Helix-based materials are found at all scales of biological systems, arguably because helical organization confers special mechanical properties at multiple length scale, ranging from DNA structures and folded peptides, to plant tendrils, seedpods, muscle fibers, etc. [1-3] These responsive biological helices have served as an … 14条地図 無料WebBicyclic peptides are next-generational therapeutics due to high conformational rigidity, metabolic stability and better cellular permeability. They combine the favourable properties of macromolecular drugs (high target specificity and affinity) with small molecules (stability and good tissue penetration) making them ideal for therapeutics with ... 14本阵型2022WebThe use of azobenzene-based crosslinker to construct light-responsive bicyclic peptides (adapted from [46]). (a) A tridentate hydroxyl amine/dichlorobenzene-containing … 14本配兵WebDec 27, 2024 · In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons to solve this problem. 14本阵型WebAug 20, 2024 · In a recent OBC publication, the group of Professor Ratmir Derda of the University of Alberta discusses a strategy to develop libraries of light-responsive (LR) ligands, which can be produced by grafting known LR structures, such as azobenzene, onto molecules with established biological activity. 14朵玫瑰代表什么意思WebOct 23, 2024 · In this paper, we describe a method for the synthesis of light-responsive (LR) bicyclic macrocycles from linear peptides composed of 20 natural amino acids. Small molecules, peptide macrocycles, and protein conjugates that reversibly turn their function on and off in response to visible light enabled the fields of photopharmacology and … 14材